Nano-machining using ion beams is the newest area of research using micro and nano focussed MeV ion beams. The nano-machining of soft solids by high energy ion beams was pioneered By F Watt and G Grime in Oxford and is now being pursued in Singapore (F Watt) and Surrey (G Grime). Preliminary work, on tissue scaffolds has shown that tissue can be successfully grown on three dimensional structures fabricated on a substrate using ion beams. Similarly, the ability to form complex three dimensional structures, with a high aspect ratio, relatively quickly, opens up applications for drug release devices, biosensors, lab on a chip and nano-reactors etc. During the next 10 years we plan to construct the World’s first nuclear nano-beam complex offering state of the art facilities to a wide range of disciplines. The applications will be truly multi-disciplinary, ranging from the life sciences, through nano-technology, fundamental materials science and space sciences, to studies to address our cultural heritage, the environment and geological sciences. This facility will open up an entirely new area of characterisation and materials modification at the nanometre scale. Potential areas of research, include the following: mapping strain fields in crystal lattices and ULSI devices; blister formation in SMART CUT materials; studying single event upsets in ULSI devices; measuring elemental composition of ambient nanoparticles; determination of metal distributions within single biological cells; mapping of metal distributions in protein crystals.